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Following synthesis in the endoplasmic reticulum, LRP1 is escorted to the Golgi by a chaperone protein, receptorassociated protein (RAP).
RAP is
Figure 3.56 Sitedirected mutagenesis of receptor associated protein (RAP) to in crease acid stability.
(A) Following binding of exogenous RAP to lowdensity lipo protein receptorrelated protein 1 (LRP1) in the cell membrane, the protein complex is taken into the cell by endocytosis.
Acidsensitive wildtype RAP is denatured in the acidic endosome and releases LRP1, which is recycled back to the cell mem brane.
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